Thymidine kinase 1 regulatory fine-tuning through tetramer formation
نویسندگان
چکیده
منابع مشابه
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. The interaction of PKM2 with phosphotyrosine-containing proteins inhibits enzyme activity and increases the availability of glycolytic metabolites to support cell proliferation. This suggests tha...
متن کاملThymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation
Prognostic markers play an important role in our understanding of tumors and how to treat them. Thymidine kinase 1 (TK1), a proliferation marker involved in DNA repair, has been shown to have independent prognostic potential. This prognostic potential includes the novel concept that upregulation of serum TK1 levels is an early event in cancer development. This same effect may also be seen in tu...
متن کاملRemark on formation of colored black holes via fine tuning
In a recent paper (gr-qc/9903081) Choptuik, Hirschmann, and Marsa have discovered the scaling law for the lifetime of an intermediate attractor in the formation of n=1 colored black holes via fine tuning. We show that their result is in agreement with the prediction of linear perturbation analysis. We also briefly comment on the dependence of the mass gap across the threshold on the radius of t...
متن کاملFine-tuning of lanthanide-monocarboxylate coordination networks through ligand decoration.
We report herein five new coordination polymers of general formula [LnNa(C(6)H(5)CO(2))(4)] where Ln = Y (6), Tb (7), Er (8), [DyNa(CH(3)CO(2))(4)(MeOH)] (9) and [DyNa(C(3)H(7)CO(2))(4)] (10). Single crystal structure analyses revealed that all compounds have a repeating unit containing one Ln(3+), one Na(+) and four monocarboxylate ligands (RCO(2)(-)) (R = -CH(3), -C(3)H(7), -C(6)H(5)). Compou...
متن کاملFine tuning of micropillar cavity modes through repetitive oxidations.
Repetitive wet thermal oxidations of a tapered oxide aperture in a micropillar structure are demonstrated. After each oxidation step the confined optical modes are analyzed at room temperature. Three regimes are identified. First, the optical confinement increases when the aperture oxidizes toward the center. Then, the cavity modes shift by more than 30 nm when the taper starts to oxidize throu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Journal
سال: 2013
ISSN: 1742-464X
DOI: 10.1111/febs.12154